Research projects

The T1 CRC Working Group aims to perform multicenter multidisciplinairy research. Here, we summarize our current research projects.

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STONE project

The STONE project aims to identify biomarkers for lymph node metastasis in T1 CRCs in order to improve selection of patients for adjuvant surgery.   Principal investigators: L.M.G. Moons, M.M. Lacle Project leader: Y. Backes, K.J.C. Haasnoot

Recruitment

Data analysis

Complete

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OPTICAL II study

The OPTICAL II-study aims to improve discrimination between non-invasive (benign) neoplasia and early colorectal cancer (T1 CRC) with optical diagnosis, by teaching Dutch endoscopists the OPTICAL prediction model with an e-learning module. Principal investigator: L.M.G. Moons Project leader: K.J.C. Haasnoot

Recruitment

Data analysis

Complete

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LIMERIC study

The LIMERIC-study aims to prospectively evaluate the radicality of the resected specimen after limited endoscopy assisted laparoscopic wedge resections (EWR) for the treatment of difficult colon polyps and the related costs and morbidity of the procedure.   Principal investigators: H.L. van Westreenen, W.M.U. van Grevenstein   Project leader: L. Leicher, J.F. Huisman

Recruitment

Data analysis

Complete

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SCAPURA study

The SCAPURA-study aims to prospectively evaluate the sensitivity of second-look endoscopic biopsies from the polypectomy site for residual tumor after Rx/R1 endscopic resection of a low-risk T1 CRC.   Principal investigator: F. ter Borg Project leader: Z. Post

Recruitment

Data analysis

Complete

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Contamination study

The contamination study aims to study whether tumor seeding by contamination of colonoscopy instruments could be a cause of mCRC   Principal investigator: T. Seerden

Recruitment

Data analysis

Complete

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Surgical outcomes

This study aims to assess the short term outcomes (morbidity and mortality) after surgical treatment for T1 CRC, and to compare this with surgical resection of advanced CRC   Principal investigator: K.C.M.J. Peeters Project leader: N.C.A. Vermeer

Recruitment

Data analysis

Complete

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Liquid biopsy pilot

This pilot aims to test whether liquid biopsies could be of value for risk stratification of T1 colorectal cancer    Principal investigator: M.M. Lacle, L.M.G. Moons Project leader: C. Spoto, Y. Backes

Recruitment

Data analysis

Complete

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OPTICAL I study


The OPTICAL-study aims to investigate the diagnostic accuracy of optical diagnosis of T1 CRC and T1 CRC with deep submucosal invasion in large non-pedunculated polyps in daily clinical practice.  Principal investigator: L.M.G. Moons Project leader: Y. Backes



Recruitment

Data analysis

Complete

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PADLOCK study


The PADLOCK-study aims to evaluate the safety and feasibility of a new, flat-based over the scope clip (Padlock ClipTM) for colorectal eFTR, and to explore for which indication(s) this technique is most suitable. Principal investigators:  L.M.G. Moons, F. P. Vleggaar Project leader:  Y. Backes



Recruitment

Data analysis

Complete

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