The T1 CRC Working Group aims to perform multicenter multidisciplinairy research. Here, we summarize our current research projects.
Research projects
STONE project
The STONE project aims to identify biomarkers for lymph node metastasis in T1 CRCs in order to improve selection of patients for adjuvant surgery. Principal investigators: L.M.G. Moons, M.M. Lacle Project leader: Y. Backes, K.J.C. Haasnoot
Recruitment
Data analysis
Complete
OPTICAL II study
The OPTICAL II-study aims to improve discrimination between non-invasive (benign) neoplasia and early colorectal cancer (T1 CRC) with optical diagnosis, by teaching Dutch endoscopists the OPTICAL prediction model with an e-learning module. Principal investigator: L.M.G. Moons Project leader: K.J.C. Haasnoot
Recruitment
Data analysis
Complete
LIMERIC study
The LIMERIC-study aims to prospectively evaluate the radicality of the resected specimen after limited endoscopy assisted laparoscopic wedge resections (EWR) for the treatment of difficult colon polyps and the related costs and morbidity of the procedure. Principal investigators: H.L. van Westreenen, W.M.U. van Grevenstein Project leader: L. Leicher, J.F. Huisman
Recruitment
Data analysis
Complete
SCAPURA study
The SCAPURA-study aims to prospectively evaluate the sensitivity of second-look endoscopic biopsies from the polypectomy site for residual tumor after Rx/R1 endscopic resection of a low-risk T1 CRC. Principal investigator: F. ter Borg Project leader: Z. Post / K. Gijsbers
Recruitment
Data analysis
Complete
Contamination study
The contamination study aims to study whether tumor seeding by contamination of colonoscopy instruments could be a cause of mCRC Principal investigator: T. Seerden
Recruitment
Data analysis
Complete
Surgical outcomes
This study aims to assess the short term outcomes (morbidity and mortality) after surgical treatment for T1 CRC, and to compare this with surgical resection of advanced CRC Principal investigator: K.C.M.J. Peeters Project leader: N.C.A. Vermeer
Recruitment
Data analysis
Complete
Liquid biopsy pilot
This pilot aims to test whether liquid biopsies could be of value for risk stratification of T1 colorectal cancer Principal investigator: M.M. Lacle, L.M.G. Moons Project leader: C. Spoto, Y. Backes
Recruitment
Data analysis
Complete
OPTICAL I study
The OPTICAL-study aims to investigate the diagnostic accuracy of optical diagnosis of T1 CRC and T1 CRC with deep submucosal invasion in large non-pedunculated polyps in daily clinical practice. Principal investigator: L.M.G. Moons Project leader: Y. Backes
Recruitment
Data analysis
Complete
PADLOCK study
The PADLOCK-study aims to evaluate the safety and feasibility of a new, flat-based over the scope clip (Padlock ClipTM) for colorectal eFTR, and to explore for which indication(s) this technique is most suitable. Principal investigators: L.M.G. Moons, F. P. Vleggaar Project leader: Y. Backes
Recruitment
Data analysis
Complete