The T1 CRC Working Group aims to perform multicenter multidisciplinairy research. Here, we summarize our current research projects.
Research projects
COMET T1 CRC
The aim of the COMET T1 CRC project is to develop a computer-aided diagnosis system based on artificial intelligence to improve the endoscopic recognition of early colorectal carcinoma.
In this project, we collect endoscopic images and videos of colorectal lesions in all available image enhancement techniques with the gold standard histopathology. We use this data to train and test the computer-aided diagnosis system.
Inclusion criteria
Patient ≥ 18 years old with an untreated colorectal lesion
– ≥10 mm with or without a suspicion of colorectal carcinoma
– <10 mm with a suspicion of colorectal carcinoma
Exclusion criteria
– Familial adenomatous polyposis
– Active inflammation around the colorectal lesion
Principal investigator: Erik Schoon
Coordinating researcher: Ayla Thijssen
Contact: a.thijssen@maastrichtuniversity.nl, +3143 388 1844
Recruitment
Data analysis
Complete
LIMERIC 2 study
Colonoscopy-Assisted Laparoscopic Wedge Resection (CAL-WR) is a promising local resection technique for both superficial and deeply invasive T1 colon cancer. It may bridge the gap between endoscopic local resection techniques and major oncologic surgery for tumors that are macroscopically suspected of deep submucosal invasion, thereby providing more patients with an organ-preserving treatment option. However, its long-term oncological outcomes are not yet known. Therefore, a prospective multicenter study (LIMERIC-II) commenced in January 2023, with sixteen participating centers.
Recruitment
Data analysis
Complete
LOCAL study
“Long-term oncological outcomes of eFTR after previous incomplete resection of low-risk T1 CRC”
Goal
The aim of this nationwide, multicentre, prospective cohort study is to evaluate the feasibility and oncological safety of eFTR scar excision after incomplete resection of low-risk T1 CRC. We aim to include a total of 153 patients with histologically confirmed T1 CRC less than 3 cm in diameter. Patients with additional histological risk factors other than Rx/R1 resection margins will be excluded. A second review by one of our study pathologists will be performed to confirm the absence of other histological risk factors. After eFTR scar excision, patients will be followed according to the current protocol for high-risk T1 CRC as outlined in the Dutch CRC guideline. The primary endpoint is the 2-year and 5-year luminal local recurrence rate. Secondary endpoints include the proportion of curative eFTR resections, the feasibility of complete scar excision on histology, 2-year and 5-year nodal and/or distant recurrence rates, 5-year disease-specific and overall survival, and procedure-related adverse events and safety of eFTR compared to surgery.
The aim of this nationwide, multicentre, prospective cohort study is to evaluate the feasibility and oncological safety of eFTR scar excision after incomplete resection of low-risk T1 CRC. We aim to include a total of 153 patients with histologically confirmed T1 CRC less than 3 cm in diameter. Patients with additional histological risk factors other than Rx/R1 resection margins will be excluded. A second review by one of our study pathologists will be performed to confirm the absence of other histological risk factors. After eFTR scar excision, patients will be followed according to the current protocol for high-risk T1 CRC as outlined in the Dutch CRC guideline. The primary endpoint is the 2-year and 5-year luminal local recurrence rate. Secondary endpoints include the proportion of curative eFTR resections, the feasibility of complete scar excision on histology, 2-year and 5-year nodal and/or distant recurrence rates, 5-year disease-specific and overall survival, and procedure-related adverse events and safety of eFTR compared to surgery.
Contact information
Principal investigator: Barbara A.J. Bastiaansen
Project leader: Sander C. Albers,
s.c.albers@amsterdamumc.nl
Principal investigator: Barbara A.J. Bastiaansen
Project leader: Sander C. Albers,
s.c.albers@amsterdamumc.nl
Recruitment
Data analysis
Complete
PATCH study
The PATCH study aims to validate a previously developed risk model for pedunculated T1 CRC and to train pathologists in the assessment of histopathologic features involved in the model. Principal investigators: M.M. Lacle, L.M.G. Moons, S.G. Elias. Project leader: L. van der Schee
Recruitment
Data analysis
Complete
Risk model validation
The Risk model validation project aims to investigate the performance of different existing risk models for T1 CRC. Principal investigators: L.M.G. Moons, M.M. Lacle, S.G. Elias. Project leader: K.J.C. Haasnoot
Recruitment
Data analysis
Complete
STONE project
The STONE project aims to identify biomarkers for lymph node metastasis in T1 CRCs in order to improve selection of patients for adjuvant surgery. Principal investigators: L.M.G. Moons, M.M. Lacle Project leader: Y. Backes, K.J.C. Haasnoot
Recruitment
Data analysis
Complete
OPTICAL II study
The OPTICAL II-study aims to improve discrimination between non-invasive (benign) neoplasia and early colorectal cancer (T1 CRC) with optical diagnosis, by teaching Dutch endoscopists the OPTICAL prediction model with an e-learning module. Principal investigator: L.M.G. Moons Project leader: K.J.C. Haasnoot
Recruitment
Data analysis
Complete
LIMERIC study
The LIMERIC-study aims to prospectively evaluate the radicality of the resected specimen after limited endoscopy assisted laparoscopic wedge resections (EWR) for the treatment of difficult colon polyps and the related costs and morbidity of the procedure. Principal investigators: H.L. van Westreenen, W.M.U. van Grevenstein Project leader: L. Leicher, J.F. Huisman
Recruitment
Data analysis
Complete
SCAPURA study
The SCAPURA-study aims to prospectively evaluate the sensitivity of second-look endoscopic biopsies from the polypectomy site for residual tumor after Rx/R1 endscopic resection of a low-risk T1 CRC. Principal investigator: F. ter Borg Project leader: Z. Post / K. Gijsbers
Recruitment
Data analysis
Complete
Contamination study
The contamination study aims to study whether tumor seeding by contamination of colonoscopy instruments could be a cause of mCRC Principal investigator: T. Seerden
Recruitment
Data analysis
Complete
Surgical outcomes
This study aims to assess the short term outcomes (morbidity and mortality) after surgical treatment for T1 CRC, and to compare this with surgical resection of advanced CRC Principal investigator: K.C.M.J. Peeters Project leader: N.C.A. Vermeer
Recruitment
Data analysis
Complete
Liquid biopsy pilot
This pilot aims to test whether liquid biopsies could be of value for risk stratification of T1 colorectal cancer Principal investigator: M.M. Lacle, L.M.G. Moons Project leader: C. Spoto, Y. Backes
Recruitment
Data analysis
Complete
OPTICAL I study
The OPTICAL-study aims to investigate the diagnostic accuracy of optical diagnosis of T1 CRC and T1 CRC with deep submucosal invasion in large non-pedunculated polyps in daily clinical practice. Principal investigator: L.M.G. Moons Project leader: Y. Backes
Recruitment
Data analysis
Complete
PADLOCK study
The PADLOCK-study aims to evaluate the safety and feasibility of a new, flat-based over the scope clip (Padlock ClipTM) for colorectal eFTR, and to explore for which indication(s) this technique is most suitable. Principal investigators: L.M.G. Moons, F. P. Vleggaar Project leader: Y. Backes
Recruitment
Data analysis
Complete